Part 2: Epidemiology, clinical presentation, radiological and laboratory features, treatment, and long-term outcome. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume L, Hümmert MW, Ringelstein M, Trebst C, Winkelmann A, Schwarz A, Buttmann M, Zimmermann H, Kuchling J, Franciotta D, Capobianco M, Siebert E, Lukas C, Korporal-Kuhnke M, Haas J, Fechner K, Brandt AU, Schanda K, Aktas O, Paul F*, Reindl M*, Wildemann B*.Part 1: Frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, Pache F, Stich O, Beume L, Hümmert MW, Trebst C, Ringelstein M, Aktas O, Winkelmann A, Buttmann M, Schwarz A, Zimmermann H, Brandt AU, Franciotta D, Capobianco M, Kuchling J, Haas J, Korporal-Kuhnke M, Lillevang ST, Fechner K, Schanda K, Paul F*, Wildemann B*, Reindl M*.MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, Franciotta D, Fujihara K, Jacob A, Kim HJ, Kleiter I, Kümpfel T, Levy M, Palace J, Ruprecht K, Saiz A, Trebst C, Weinshenker BG, Wildemann B.MOG-Enzephalomyelitis: Empfehlungen zu Diagnose und Antikörpertestung. Independent projects are dedicated to investigating the pathophysiological and diagnostic relevance of autoantibodies in other inflammatory diseases of the central and peripheral nervous system (e.g., neuromyelitis optica spectrum disorder, paraneoplastic and non-paraneoplastic cerebellar ataxia, limbic encephalitis, peripheral neuropathy, Susac syndrome see here and here).īrigitte.wildemann(at) Our work focuses on investigating the diagnostic, prognostic, und pathophysiological relevance of antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) in patients with demyelinating disorders of the central nervous system (multiple sclerosis, neuromyelitis optica, transverse myelitis, optic neuritis, brainstem encephalitis) and on developing and establishing new, recombinant assays for the detection of MOG-IgG. In most cases, the disease takes a relapsing course. The phenoytpical spectrum of MOG-EM includes mainly optic neuritis, myelitis and/or brainstem encephalitis as well as ADEM- and MS-like manifestations. MOG encephalomyelitis (MOG-EM) is an inflammatory, demyelinating disorder of the central nervous system. Principal investigators: Sven Jarius, Brigitte Wildemann PMID 8530032.Diagnostic and pathophysiological relevance of autoantibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) “The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization”. “Aquaporins and Their Regulation after Spinal Cord Injury”. Halsey, Andrea Conner, Alex Bill, Roslyn Logan, Ann Ahmed, Zubair (). Interpretation of the results must be made in the context of clinical signs and symptoms. Anti-MOG antibodies are NOT a reliable biomarker in adult onset multiple sclerosis. There is consensus that anti-MOG antibodies are important in both pediatric and adult demyelination, and the clinical association of MOG autoantibody-associated demyelination has been refined to include acute disseminated encephalomyelitis (ADEM), relapsing and bilateral optic neuritis, and transverse myelitis. MOG is also considered to serve a function as an adhesion molecule to provide structural integrity to the myelin sheath. MOG (Myelin oligodendrocyte glycoprotein) is a glycoprotein believed to be important in the myelination of nerves in the central nervous system. Autoantibodies against aquaporin-4 is prevalent in neuromyelitis optica (NMO). AQP4 facilitates water movement near cerebrospinal fluid and vasculature. Aquaporin-4 is one of the exclusive aquaporin proteins found in the central nervous system – particularly being the most prevalent aquaporin protein in the cerebellum and spinal cord grey matter. Aquaporin-4, also known as AQP4 or NMO-IgG, is a water channel membrane protein that conducts water through the cell membrane. Mitogen’s Neuromyelitis Spectrum assay is an autoimmune diagnostic test that detects autoantibodies to Aquaporin 4 & Anti-Myelin Oligodendrocyte Glycoproteins (MOG).
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |